Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on Sep 7, 2018.
IRJP 1 (1) 2010 324-332. Handbook of pharmaceutical excipients. Telcordia software to calculate the reliability prediction of electronic equipment based on the Telcordia (Bellcore). The aim of this study was to evaluate the compatibility of trioxsalen with pharmaceutical excipients used. Handbook of pharmaceutical. Telcordia Sr 332 Handbook Of. New South Wales; Canadian guideline frequent consumer site gc.ca; Milk guidelines for 2 year toddler; 1961 merriam-webster third new international dictionary definition globalizat. Fu W, Carbohydrate Research 303, 1997, 327-332. Bouriotis V, Martinou A, Kafetzopoulos D, Carbohydrate Research, 273, 1995, 235-242. Bhumkar Dr, Pokharkar VB, “Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate” AAPS Pharmasci Tech. 7(2) 2006, 50. The Handbook of Pharmaceutical Excipients collects together essential data on the physical properties of excipients as well as providing information on their safe use and applications. All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names.
What is it?
Microcrystalline cellulose (C6H10O5)n is refined wood pulp. It is a white, free-flowing powder. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. In large quantities it provides dietary bulk and may lead to a laxative effect.
Microcrystalline cellulose is a commonly used excipient in the pharmaceutical industry. It has excellent compressibility properties and is used in solid dose forms, such as tablets. Tablets can be formed that are hard, but dissolve quickly. Microcrystalline cellulose is the same as cellulose, except that it meets USP standards.[1]
It is also found in many processed food products, and may be used as an anti-caking agent, stabilizer, texture modifier, or suspending agent among other uses. According to the Select Committee on GRAS Substances, microcrystalline cellulose is generally regarded as safe when used in normal quantities. [2][3][4]
[1] [1]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] FDA’s SCOGS database; Microcrystalline cellulose, Report No. 25, 1979.; ID Code: 9004-57-3; Accessed July 28, 2011.
[3] Food and Agricultural Organization of the United Nations. Corporate Document Repository. Compendium of Food Additive Specifications, Addendum 5. Microcrystalline cellulose. http://www.fao.org/docrep/W6355E/w6355e0l.htm Accessed July 28, 2011
Pharmaceutical Excipients
[4] US Dept of Agriculture, Agricultural Marketing Service. Cellulose processing. Executive Summary. Accessed 7/28/2011.
Further information
Telcordia Sr 332 Handbook
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